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Hypoglycemia in Type 2 Diabetes—Consequences and Risk Assessment

Seaquist ER, Oz G. Sweet and low: measuring brain glucose during hypoglycemia. Brain glucose concentrations in patients with type 1 diabetes and hypoglycemia unawareness. J Neurosci Res ; Measurement of cerebral oxidative glucose consumption in patients with type 1 diabetes mellitus and hypoglycemia unawareness using 13C nuclear magnetic resonance spectroscopy. Metabolism ; Brain glucose concentrations in healthy humans subjected to recurrent hypoglycemia.

Effect of acute and recurrent hypoglycemia on changes in brain glycogen concentration. Brain glycogen content and metabolism in subjects with type 1 diabetes and hypoglycemia unawareness. J Cereb Blood Flow Metab ; Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo.

Effect of hyperketonemia and hyperlacticacidemia on symptoms, cognitive dysfunction, and counterregulatory hormone responses during hypoglycemia in normal humans.

PDF Hypoglycemia in Diabetes: Pathophysiology, Prevalence, and Prevention Philip E. Cryer M.D.

Protection by lactate of cerebral function during hypoglycaemia. Lancet ; Brain function rescue effect of lactate following hypoglycaemia is not an adaptation process in both normal and type 1 diabetic subjects. Brain substrate utilisation during acute hypoglycaemia. Brain oxygen utilization is unchanged by hypoglycemia in normal humans: lactate, alanine, and leucine uptake are not sufficient to offset energy deficit. Blood lactate is an important energy source for the human brain. The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy.

J Neurosci ; Increased brain lactate concentrations without increased lactate oxidation during hypoglycemia in type 1 diabetic individuals. Diabetes May 28 Epub ahead of print. Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia. Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia. Brain insulin action regulates hypothalamic glucose sensing and the counterregulatory response to hypoglycemia.

Impaired counterregulatory response to hypoglycemia and impaired glucose tolerance in brain glucose transporter 4 GLUT4 knockout mice. Elimination of hypoglycemia from the lives of people affected by diabetes. Effects of the selective serotonin reuptake inhibitor fluoxetine on counterregulatory responses to hypoglycemia in individuals with type 1 diabetes. The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia.

Ramanathan R, Cryer PE.

ISBN 13: 9781580403269

Adrenergic mediation of hypoglycemia-associated autonomic failure. Opiate blockade enhances hypoglycemic counterregulation in normal and insulin-dependent diabetic subjects. Opioid receptor blockade improves hypoglycemia-associated autonomic failure in type 1 diabetes mellitus.

J Clin Endocrinol Metab ; Fructose amplifies counterregulatory responses to hypoglycemia in humans. Death during intensive glycemic therapy of diabetes: mechanisms and implications. Am J Med ; Activation of human medial prefrontal cortex during autonomic responses to hypoglycemia. Evolution and resolution of human brain perfusion responses to the stress of induced hypoglycemia. Neuroimage ; Grissom N, Bhatnagar S.

Hypoglycemia in Diabetes Pathophysiology Prevalence and Prevention

Habituation to repeated stress: get used to it. Neurobiol Learn Mem ; Lesions of the posterior paraventricular thalamus block habituation of hypothalamic-pituitary-adrenal responses to repeated restraint. J Neuroendocrinol ; Predictability of chronic intermittent stress: effects on sympathetic-adrenal medullary responses of laboratory rats.

Behav Neural Biol ; Thalamic activation during slightly subphysiological glycemia in humans.

Hypoglycemia in diabetes : pathophysiology, prevalence, and prevention (eBook, ) [ojysuharoweq.tk]

Medial prefrontal cortex activity can disrupt the expression of stress response habituation. Neuroscience ; N Engl J Med ; 3. J Clin Invest ; 4. N Engl J Med ; 5. Science ; 6.

Diabetes ;Suppl:AA 7. J Clin Invest ; 8. Diabetes ; 9. N Engl J Med ; Diabetes ; Endocrinology ; J Clin Invest ; Diabetes Care ; Diabetes Metab Res Rev ; Hypoglycemia in type 1 diabetes.

Am J Physiol ;EE J Neurochem ; Diabetologia ; J Neurosci Res ; Metabolism ; Gruetter R. Glycogen: the forgotten cerebral energy store. J Cereb Blood Flow Metab ; Start on. Show related SlideShares at end. WordPress Shortcode. Published in: Education.

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